Chemoenzymatic Deracemization of Chiral Sulfoxides.

Published in: Angewandte Chemie (International ed. in English) (2018)

The highly enantioselective enzyme methionine sulfoxide reductase A was combined with an oxaziridine-type oxidant in a biphasic setup for the deracemization of chiral sulfoxides. Remarkably, high ee values were observed with a wide range of substrates, thus providing a practical route for the synthesis of enantiomerically pure sulfoxides.

Keyphrases

capillary electrophoresis
ionic liquid
mass spectrometry