Decoding Endothelial MPL and JAK2V617F Mutation: Insight Into Cardiovascular Dysfunction in Myeloproliferative Neoplasms.

Haotian ZhangNicholas KafeitiKyla MasarikSandy LeeXiaoxi YangHaoyi Zheng Huichun Zhan

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

JAK2V617F mutant endothelial cells play a critical role in the development of cardiovascular diseases in JAK2V617F-positive MPNs, and endothelial MPL could be a promising therapeutic target for preventing or ameliorating cardiovascular complications in these patients.

Keyphrases

endothelial cells
end stage renal disease
cardiovascular disease
ejection fraction
chronic kidney disease
newly diagnosed
risk factors
high glucose
metabolic syndrome
coronary artery disease
vascular endothelial growth factor