Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy.
Michael HwangJenna Vanliere CanzonieroSamuel RosnerGuangfan ZhangJames R WhiteZineb BelcaidChristopher CherryArchana BalanGavin PereiraAlexandria CurryNoushin NiknafsJiajia ZhangKellie N SmithLavanya SivapalanJamie E ChaftJoshua E ReussKristen MarroneJoseph C MurrayQing Kay LiVincent LamBenjamin P LevyChristine HannVictor E VelculescuJulie R BrahmerPatrick M FordeTanguy Y SeiwertValsamo AnagnostouPublished in: Journal for immunotherapy of cancer (2022)
Our findings suggest that early dynamics in peripheral blood immune cell subsets reflect changes in the tumor microenvironment and capture antitumor immune responses, ultimately reflecting clinical outcomes with immune checkpoint blockade.