In vitro and in vivo Antimicrobial Activities of Ceftazidime/Avibactam Alone or in Combination with Aztreonam Against Carbapenem-Resistant Enterobacterales.
Guoping LuHao TangZhaoxin XiaWensu YangHuaming XuZhen LiuShenwang NiZhaofei WangJilu ShenPublished in: Infection and drug resistance (2022)
Our in vitro results showed that CZA had a good antimicrobial effect on the KPC-producing and OXA-producing strains. CZA combined with ATM showed synergistic bacteriostatic or bactericidal activity against NDM-, IMP-, KPC+IMP-, KPC+NDM-producing strains. The combination of CZA and ATM reduced mortality and prolonged lifespan of mice infected with NDM-, IMP-, KPC+IMP-, and KPC+NDM-producing strains, which provides fundamental knowledge for improving treatment strategies and initializing clinical trials.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- multidrug resistant
- clinical trial
- dna damage
- staphylococcus aureus
- gram negative
- dna repair
- dna damage response
- cardiovascular disease
- type diabetes
- acinetobacter baumannii
- risk factors
- coronary artery disease
- cancer therapy
- high fat diet induced
- phase iii
- drosophila melanogaster