Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis.

Misty GoodTianjiao ChuPatricia ShawLora McClainAustin ChamberlainCarlos CastroJamie M RimerBelgacem MihiQingqing GongLila S NolanKrista CookseyLaura LinnemanPranjal AgrawalDavid N FinegoldDavid Peters

Published in: Clinical epigenetics (2020)

We have defined the intestinal epigenomic and transcriptomic signatures during surgical NEC, which will advance our understanding of disease pathogenesis and may enable the development of novel precision medicine approaches for NEC prediction, diagnosis and phenotyping.

Keyphrases

machine learning
high throughput
single cell
rna seq
gene expression
low birth weight
neural network