Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjögren's syndrome.
Ana P LopesMaarten R HillenEleni ChouriSofie L M BloklandCornelis P J BekkerAike A KruizeMarzia RossatoJoel A G van RoonTimothy R D J RadstakePublished in: PloS one (2018)
We were unable to identify any serum sncRNAs with differential expression in pSS patients. However, we show that circulating miRNA levels are associated with disease parameters in pSS patients and can be used to distinguish pSS patients with more severe B cell hyperactivity. As several of these miRNAs are implicated in the regulation of B cells, they may play a role in the perpetuation of the disease.