Utilizing the Social Cognitive Career Theory (SCCT) as the theoretical framework, this study proposed a moderated mediation model investigating the complex functioning mechanisms of how self-efficacy beliefs and leader support can be related to research motivation among Chinese university teachers. A group of 310 Chinese teachers working in different universities completed an online survey. Results from structural equation modeling (SEM) analysis revealed distinct influencing paths from the predictor variables (i.e., self-efficacy and leader support) to the outcome variables (i.e., intrinsic and extrinsic research motivation). Specifically, self-efficacy beliefs predicted both mastery and performance goal orientations; mastery goal orientation, in turn, positively affected intrinsic and extrinsic research motivation. In contrast, leader support was non-significant for the both types of goal orientations, but exerted strong direct influences on the both types of research motivation. Bootstrapping methods in SEM showed that it was primarily the mastery goal orientation that mediated the relationships between self-efficacy beliefs and research motivation. Furthermore, the results from the SEM and simple slope analysis revealed that leader support moderated the association between self-efficacy and extrinsic research motivation.