Antiviral innate immunity is the first line of defence against viruses. The interferon (IFN) signaling pathway, the DNA damage response (DDR), apoptosis, endoplasmic reticulum (ER) stress, and autophagy are involved in antiviral innate immunity. Viruses abrogate the antiviral immune response of cells to replication in various ways. Viral genes/proteins play a key role in evading antiviral innate immunity. Here, we will discuss the interference of viruses with antiviral innate immunity and the strategy for identifying viral gene/protein immune evasion.
Keyphrases
- immune response
- signaling pathway
- sars cov
- dna damage response
- induced apoptosis
- endoplasmic reticulum
- cell cycle arrest
- endoplasmic reticulum stress
- genome wide
- oxidative stress
- cell death
- dendritic cells
- pi k akt
- genome wide identification
- epithelial mesenchymal transition
- dna methylation
- cell proliferation
- toll like receptor