Compound Muscle Action Potential and Myosin-Loss Pathology in Patients With Critical Illness Myopathy: Correlation and Prognostication.
Shahar ShellyPannathat SoontrapaNicolas N MadiganMichael J PolzinTarun D SinghSri Raghav S SistaPritikanta PaulSherri A BraksickBing LiaoAnthony J WindebankAndrea J BoonWilliam J LitchyMargherita MiloneTeerin LiewluckPublished in: Neurology (2024)
Myosin loss occurred in 70% of the patients with CIM with prolonged CMAP duration. Longer CMAP duration predicts myosin-loss pathology. The extent of myosin loss marginally correlates with the mortality rate. Our findings highlight the potential prognostic values of CMAP duration and myosin loss severity in predicting disease outcome.