MnO2-Based Nanoplatform Serves as Drug Vehicle and MRI Contrast Agent for Cancer Theranostics.
Mei ZhangLei XingHengte KeYu-Jing HePeng-Fei CuiYong ZhuGe JiangJian-Bin QiaoNa LuHuabing ChenHu-Lin JiangPublished in: ACS applied materials & interfaces (2017)
Multidrug resistance (MDR) greatly impedes the therapeutic efficacy of chemotherapeutic agents. Overexpression of ATP-binding cassette (ABC) transporters, such as P-gp, on the surface of tumor cells is a major mechanism in MDR. In this study, we fabricated manganese dioxide (MnO2)/doxorubicin (DOX)-loaded albumin nanoparticles (BMDN) for magnetic resonance imaging and reversing MDR in resistant tumor. BMDN facilitated the delivery of DOX into MDR tumor cells through their MDR reversal effects including enhanced cellular uptake, reduced drug efflux, and decreased hypoxic tumor microenvironment. BMDN also acted as an effective MRI contrast agent, thereby causing good in vitro and in vivo T1-weighted imaging.
Keyphrases
- contrast enhanced
- multidrug resistant
- magnetic resonance imaging
- magnetic resonance
- computed tomography
- cancer therapy
- drug delivery
- diffusion weighted imaging
- cell proliferation
- emergency department
- transcription factor
- papillary thyroid
- photodynamic therapy
- drug release
- young adults
- network analysis
- walled carbon nanotubes