Immobilising an acid-cleavable dimeric phthalocyanine on gold nanobipyramids for intracellular pH detection and photodynamic elimination of cancer cells.
Yue CaoRoy C H WongEvelyn Y XueHan ZhangJie WangYan DingLingzhi WuFeng ChenJianfang WangDennis K P NgPublished in: The Analyst (2024)
An acetal-linked dimeric phthalocyanine has been synthesised and immobilised on the surface of gold nanobipyramids. The resulting nanocomposite serves as a highly sensitive probe for intracellular pH through its acid-responsive fluorescence and surface-enhanced Raman scattering signals. The phthalocyanine units released in the acidic intracellular environment can also effectively eliminate the cancer cells upon light irradiation, rendering this simple fabricated nanosystem a bimodal and bifunctional theranostic agent.
Keyphrases
- photodynamic therapy
- reactive oxygen species
- fluorescence imaging
- cancer therapy
- living cells
- quantum dots
- highly efficient
- single molecule
- label free
- silver nanoparticles
- fluorescent probe
- real time pcr
- loop mediated isothermal amplification
- reduced graphene oxide
- energy transfer
- molecularly imprinted
- mass spectrometry
- carbon nanotubes
- metal organic framework