The role of PCSK9 in glomerular lipid accumulation and renal injury in diabetic kidney disease.
Mei-Yan WuChang-Yun YoonJimin ParkGyuri KimBo Young NamSeonghun KimJung Tak ParkSeung-Hyeok HanShin-Wook KangTae-Hyun YooPublished in: Diabetologia (2024)
The downregulation of PCSK9 in podocytes is associated with lipid accumulation, which leads to mitochondrial dysfunction, cell apoptosis and renal injury. This study sheds new light on the potential involvement of PCSK9 in the pathophysiology of glomerular lipid accumulation and podocyte injury in DKD.