The Origin of Skin Dendritic Cell Network and Its Role in Psoriasis.
Tae Gyun KimSung Hee KimMin-Geol LeePublished in: International journal of molecular sciences (2017)
Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DCs usually denotes conventional DCs (cDCs). Skin contains a unique DC network mainly composed of embryo precursor-derived epidermal Langerhans cells (LCs) and bone marrow-derived dermal cDCs, which can be further classified into type 1 (cDC1) and type 2 (cDC2) subsets. Psoriasis is a chronic inflammatory skin disease, which is principally mediated by IL-23/IL-17 cytokine axis. In the psoriatic skins, DCs are prominent cellular sources for TNF-α and IL-23, and the use of blocking antibodies against TNF-α and IL-23 leads to a significant clinical improvement in psoriatic patients. Recent elegant human and mouse studies have shown that inflammation-induced inflammatory DCs, LCs, dermal cDC2, and monocyte-derived DCs are pivotal DC subsets in psoriatic inflammation. Thus, targeting specific pathogenic DC subsets would be a potential strategy for alleviating and preventing DC-derived IL-23-dependent psoriatic inflammation and other inflammatory dermatoses in the future.
Keyphrases
- dendritic cells
- immune response
- rheumatoid arthritis
- oxidative stress
- wound healing
- regulatory t cells
- disease activity
- ankylosing spondylitis
- peripheral blood
- induced apoptosis
- endothelial cells
- systemic lupus erythematosus
- end stage renal disease
- cell cycle
- soft tissue
- newly diagnosed
- cancer therapy
- ejection fraction
- toll like receptor
- case report
- drinking water
- inflammatory response
- climate change
- induced pluripotent stem cells
- cell cycle arrest
- cell death
- endoplasmic reticulum stress
- human health
- heat shock
- patient reported