Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1.

Madeleine BirgerssonRajitha IndukuriLinnéa LindquistLina StepanauskaiteQing LuoQiaolin DengAmena ArcherCecilia Williams

Published in: BMC biology (2023)

By characterizing the genome-wide endogenous ERβ chromatin binding, gene regulations, and extensive crosstalk between ERβ and LRH-1, along with experimental corroborations, our data offer genome-wide mechanistic underpinnings of ovarian physiology and fertility.

Keyphrases

genome wide
dna methylation
endoplasmic reticulum
estrogen receptor
copy number
breast cancer cells
gene expression
dna damage
oxidative stress
machine learning
young adults
single cell