Time of day as a critical variable in biology.

Randy J NelsonJacob R BumgarnerJennifer A LiuJharnae A LoveO Hecmarie Meléndez-FernándezDarius D Becker-KrailWilliam H WalkerJames C WaltonA Courtney DeVriesBrian J Prendergast

Published in: BMC biology (2022)

Circadian rhythms are a defining feature of biological systems, and knowing when in the circadian day these systems are evaluated is fundamentally important information. Failing to account for time of day hampers reproducibility across laboratories, complicates interpretation of results, and reduces the value of data based predominantly on nocturnal animals when extrapolating to diurnal humans.

Keyphrases

blood pressure
machine learning
obstructive sleep apnea
electronic health record
deep learning
big data
health information
sleep quality
sleep apnea
social media
depressive symptoms
neural network