Anti-PD-1 treatment protects against seizure by suppressing sodium channel function.
Yuling YangZhiyun ChenJing ZhouShize JiangGuoxiang WangLi WanJiangning YuMin JiangYulong WangJie HuXu LiuYun WangPublished in: CNS neuroscience & therapeutics (2023)
Our study reveals that neuronal PD-1 plays an important role in epilepsy and that anti-PD-1 treatment protects against seizures by suppressing sodium channel function, identifying anti-PD-1 treatment as a novel therapeutic strategy for epilepsy.