Comparative analysis of adeno-associated virus serotypes for gene transfer in organotypic heart slices.

Zihou LiuKristin KloseSebastian NeuberMeng JiangManfred GossenChristof Stamm

Published in: Journal of translational medicine (2020)

We have established a readily available mouse organotypic heart slice culture model and provided evidence that AAV6 may be a promising gene therapy vector for heart failure and other cardiac diseases.

Keyphrases

gene therapy
heart failure
left ventricular
atrial fibrillation
genome wide
cardiac resynchronization therapy
computed tomography
dna methylation
transcription factor