Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy.
Sandra BrosdaLauren G AoudeVanessa F BonazziKalpana PatelJames M LonieClemence J BelleFelicity NewellLambros T KoufariotisVenkateswar AddalaMarjan M Naeininull nullJohn V PearsonLutz KrauseNicola WaddellAndrew P BarbourPublished in: Genome medicine (2024)
This study demonstrates the high intra-tumour heterogeneity in OAC, as well as indicators for treatment-induced changes during tumour evolution. Intra-tumour heterogeneity remains a problem for successful treatment strategies in OAC.