A Genetic Risk Score for Atrial Fibrillation Predicts the Response to Catheter Ablation.

Won Seok ChoeJun Hyuk KangEue-Keun Choi Seung Yong Shin Steven A Lubitz Patrick T Ellinor Seil Oh Hong Euy Lim

Published in: Korean circulation journal (2018)

Our novel GRS using 5 AF-susceptible SNPs was strongly associated with AF recurrence after catheter ablation in Korean population, beyond clinical risk factors. Further efforts are warranted to construct a generalizable, robust genetic prediction model which can guide the optimal treatment strategies.

Keyphrases

catheter ablation
atrial fibrillation
left atrial
genome wide
left atrial appendage
risk factors
oral anticoagulants
direct oral anticoagulants
heart failure
copy number
percutaneous coronary intervention
dna methylation
gene expression
left ventricular
venous thromboembolism