Biological Aging in People Living with HIV on Successful Antiretroviral Therapy: Do They Age Faster?
Sara Svensson AkusjärviUjjwal NeogiPublished in: Current HIV/AIDS reports (2023)
Biological aging, defined by the epigenetic alterations analyzed by the DNA methylation pattern, has been reported in PLWH with cART that points towards epigenetic age acceleration. The hastened development of specific clinical geriatric syndromes like cardiovascular diseases, metabolic syndrome, cancers, liver diseases, neurocognitive diseases, persistent low-grade inflammation, and a shift toward glutamate metabolism in PLWH may potentiate a metabolic profile at-risk for accelerated aging.
Keyphrases
- dna methylation
- low grade
- metabolic syndrome
- antiretroviral therapy
- gene expression
- high grade
- cardiovascular disease
- genome wide
- oxidative stress
- hiv infected
- human immunodeficiency virus
- hiv positive
- hiv aids
- hiv infected patients
- insulin resistance
- bipolar disorder
- type diabetes
- cardiovascular risk factors
- skeletal muscle
- south africa
- adipose tissue
- young adults
- coronary artery disease