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Biological Aging in People Living with HIV on Successful Antiretroviral Therapy: Do They Age Faster?

Sara Svensson AkusjärviUjjwal Neogi
Published in: Current HIV/AIDS reports (2023)
Biological aging, defined by the epigenetic alterations analyzed by the DNA methylation pattern, has been reported in PLWH with cART that points towards epigenetic age acceleration. The hastened development of specific clinical geriatric syndromes like cardiovascular diseases, metabolic syndrome, cancers, liver diseases, neurocognitive diseases, persistent low-grade inflammation, and a shift toward glutamate metabolism in PLWH may potentiate a metabolic profile at-risk for accelerated aging.
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