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Prognostic value of O-6-methylguanine-DNA methyltransferase (MGMT) protein expression in glioblastoma excluding nontumour cells from the analysis.

Rikke Hedegaard DahlrotJ DowsettS FosmarkA MalmströmR HenrikssonH BoldtK de StrickerMia Dahl SørensenH S PoulsenM LysiakP SöderkvistJ RosellS HansenB W Kristensen
Published in: Neuropathology and applied neurobiology (2017)
Our data indicate that MGMT protein expression in tumour cells has an independent prognostic significance. Exclusion of nontumour cells contributed to a more exact analysis of tumour-specific MGMT protein expression. This should be incorporated in future studies evaluating MGMT status before potential integration into clinical practice.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • clinical practice
  • endoplasmic reticulum stress
  • cell death
  • electronic health record
  • signaling pathway
  • circulating tumor
  • human health