Prognostic value of O-6-methylguanine-DNA methyltransferase (MGMT) protein expression in glioblastoma excluding nontumour cells from the analysis.
Rikke Hedegaard DahlrotJ DowsettS FosmarkA MalmströmR HenrikssonH BoldtK de StrickerMia Dahl SørensenH S PoulsenM LysiakP SöderkvistJ RosellS HansenB W KristensenPublished in: Neuropathology and applied neurobiology (2017)
Our data indicate that MGMT protein expression in tumour cells has an independent prognostic significance. Exclusion of nontumour cells contributed to a more exact analysis of tumour-specific MGMT protein expression. This should be incorporated in future studies evaluating MGMT status before potential integration into clinical practice.