The Impact of LRRK2 G2019S on Parkinson's Disease: Clinical Phenotype and Treatment in Tunisian Patients.

Guedi Ali BarrehIkram SghaierYoussef AbidaAlya GharbiAmina NasriSaloua MrabetAmira SouissiMouna Ben DjebaraSameh TrabelsiImen KacemAmina Gargouri-BerrechidRiadh Gouider

Published in: Journal of movement disorders (2024)

The present study demonstrated that the variability of the clinical profile among Tunisian PD patients was explained by the incomplete penetrance of LRRK2-G2019S, which increased with age. Further studies using biomarker and disease progression data are necessary to improve PD management.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
machine learning
electronic health record
big data
deep learning
artificial intelligence