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Comparison of Poly (ADP-ribose) Polymerase Inhibitors (PARPis) as Maintenance Therapy for Platinum-Sensitive Ovarian Cancer: Systematic Review and Network Meta-Analysis.

Amos StemmerInbal ShafranSalomon M StemmerDaliah Tsoref
Published in: Cancers (2020)
No statistically significant difference was found between the three PARPis with respect to PFS or OS (overall and in subpopulations by BRCA status). There is, however, a statistical difference in toxicity as niraparib is associated with a greater risk for thrombocytopenia and neutropenia.
Keyphrases
  • oxidative stress
  • breast cancer risk
  • clinical evaluation