Gingival fibroblasts prevent BMP-mediated osteoblastic differentiation.

Mandeep S GhumanMaher Al-MasriGuilherme XavierMartyn T CobourneIan J McKayFrancis J Hughes

Published in: Journal of periodontal research (2018)

Factors secreted by gingival fibroblasts inhibit BMP-induced bone formation and a range of BMP inhibitors are constitutively expressed in gingival connective tissues. These inhibitors, particularly Gremlin1, may limit coronal alveolar bone regenerative potential during oral and periodontal surgery.

Keyphrases

mesenchymal stem cells
bone regeneration
stem cells
minimally invasive
extracellular matrix
gene expression
coronary artery bypass
cell therapy
bone marrow
bone mineral density
drug induced