Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom.
Isadora Sousa de OliveiraRafaella Varzoni ManziniIsabela Gobbo FerreiraIara Aimê CardosoKarla de Castro Figueiredo BordonAna Rita Thomazela MachadoLusânia Maria Greggi AntunesJosé Cesar RosaEliane Candiani ArantesPublished in: The journal of venomous animals and toxins including tropical diseases (2018)
Thus, our results demonstrate that non-RGD disintegrin from C. d. collilineatus induces low cytotoxicity and inhibits migration of human breast cancer cells. Therefore, it may be a very useful molecular tool for understanding ECM-cell interaction cancer-related mechanisms involved in an important integrin family that highlights molecular aspects of tumorigenesis. Also, non-RGD disintegrin has potential to serve as an agent in anticancer therapy or adjuvant component combined with other anticancer drugs.