Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
Ju-Sheng ZhengJian'an LuanEleni SofianopoulouFumiaki ImamuraIsobel D StewartFelix R DayMaik PietznerEleanor WheelerLuca A LottaThomas E GundersenPilar AmianoEva ArdanazMaría-Dolores ChirlaqueGuy FagherazziPaul W FranksRudolf KaaksNasser LaoualiFrancesca Romana ManciniPeter M NilssonN Charlotte Onland-MoretAnja OlsenKim OvervadSalvatore PanicoDomenico PalliFulvio RicceriOlaf RolandssonAnnemieke M W SpijkermanMaría-José SánchezMatthias Bernd SchulzeNúria SalaSabina SieriAnne TjønnelandRosario TuminoYvonne T van der SchouwElisabete WeiderpassElio RiboliJohn DaneshAdam S ButterworthStephen J SharpClaudia LangenbergNita G ForouhiNicholas J WarehamPublished in: Diabetes care (2020)
These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.