Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion.
Xun WuYi-Shing Lisa ChengMathew MatthenAngela YoonGary K SchwartzShashi BalaAlison M TaylorFatemeh Momen-HeraviPublished in: Journal of experimental & clinical cancer research : CR (2021)
Our results demonstrate that miR-34a directly targets MET and maintains anti-tumor immune activity. We propose miR-34a as a potential new therapeutic approach for HNSCC.