Intratumoral heterogeneity affects tumor regression and Ki67 proliferation index in perioperatively treated gastric carcinoma.

Magnus Kock Am BrinkLaura Sophie DunstHans-Michael BehrensSandra KrügerThomas BeckerChristoph Roecken

Published in: British journal of cancer (2022)

Digital image analysis in tumor regression evaluation might help overcome inter- and intraobserver variability and validate classification systems. Ki67 may serve as a sensitivity predictor for chemotherapy and an indicator of ITH.

Keyphrases

neoadjuvant chemotherapy
machine learning
deep learning
single cell
locally advanced
chemotherapy induced