A comprehensive evaluation of methods for Mendelian randomization using realistic simulations and an analysis of 38 biomarkers for risk of type 2 diabetes.

Published in: International journal of epidemiology (2021)

The relative performance of different MR methods depends heavily on the sample sizes of the underlying GWAS, the proportion of valid instruments and the validity of the InSIDE assumption. Down-sampling analysis can be used in large GWAS for the possible detection of bias in the MR methods.

Keyphrases

type diabetes
contrast enhanced
cardiovascular disease
magnetic resonance imaging
molecular dynamics
computed tomography
insulin resistance
adipose tissue
glycemic control
patient reported outcomes
real time pcr