Scorpion toxin inhibits the voltage-gated proton channel using a Zn2+ -like long-range conformational coupling mechanism.

Dongfang TangYuqin YangZhen XiaoJiahui XuQiuchu YangHan DaiSongping LiangCheng TangHao DongZhonghua Liu

Published in: British journal of pharmacology (2020)

Our results suggest that the Zn2+ binding pocket in HV 1 channel might be a hotspot for modulators and valuable for designing HV 1 channel ligands. Moreover, AGAP/W38F is a useful molecular probe to study HV 1 channel and a lead compound for drug development.

Keyphrases

escherichia coli
single molecule
molecular dynamics
molecular dynamics simulations
transition metal