A pitfall in hemoglobin A1c measurement with high performance liquid chromatography method in the diagnosis of onset of fulminant type 1 diabetes mellitus.

Yasuharu OeTakatoshi AnnoYukari KatsuharaRyo SugaharaMiki KobayashiMieko YakusueMasayo TamuraYukiko KimuraFumiko KawasakiKohei Kaku Hideaki KanetoAkira Kitanaka

Published in: Journal of diabetes investigation (2022)

We showed a case with the onset of fulminant type 1 diabetes mellitus (FT1DM) whose HbA1c could not be measured with HPLC method. We think that the reason why his HbA1c was not be detected was associated with the presence of labile hemoglobin A1c (LHbA1c). These result mean that it is possible that LHbA1c can bring about a pitfall on HPLC method in diagnosis of onset of FT1DM.

Keyphrases

liver failure
high performance liquid chromatography
simultaneous determination
tandem mass spectrometry
solid phase extraction
mass spectrometry
glycemic control
ms ms
liquid chromatography
type diabetes
cardiovascular risk factors
red blood cell
cardiovascular disease
adipose tissue
metabolic syndrome