Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease.

Jamileh Ghalami Tourandokht Baluchnejad Mojarad Monireh Mansouri Safoura Khamse Mehrdad Roghani

Published in: Basic and clinical neuroscience (2021)

These obtained findings evidently designate neuroprotective property of paeonol in 6-OHDA murine model of PD that is exerted via easing of oxidative stress, apoptosis, astrogliosis, and its advantageous effect is to some extent mediated via mGluR III/GABAA pathway.

Keyphrases

oxidative stress
endoplasmic reticulum stress
dna damage
induced apoptosis
diabetic rats
ischemia reperfusion injury
cell cycle arrest
cell death
cerebral ischemia
signaling pathway
cell proliferation
blood brain barrier
heat stress