Castleman's Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up.
Lokesh K JhaLaura L UlmerMarco A Olivera-MartinezTimothy M McCashlandKai FuFedja A RochlingPublished in: Case reports in hepatology (2018)
A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman's disease. Treatment included valganciclovir, rituximab, and prednisone taper with eventual discontinuation. Quantitative HHV8 DNA was initially 611,000 DNA copies/mL and was later undetectable at 6 months following treatment and remained undetectable at 3-year follow-up.
Keyphrases
- epstein barr virus
- diffuse large b cell lymphoma
- lymph node
- circulating tumor
- bone marrow
- cell free
- single molecule
- high resolution
- endothelial cells
- squamous cell carcinoma
- ultrasound guided
- sleep quality
- combination therapy
- early stage
- depressive symptoms
- radiation therapy
- mass spectrometry
- photodynamic therapy
- sentinel lymph node
- chronic lymphocytic leukemia
- replacement therapy