Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma.

Christos DimitrakopoulosSravanth Kumar HindupurMarco ColombiDritan LikoCharlotte K Y NgSalvatore PiscuoglioJonas BehrAriane L MooreJochen SingerHans-Joachim RuscheweyhMatthias S MatterDirk MossmannLuigi M TerraccianoMichael N HallNiko Beerenwinkel

Published in: BMC genomics (2021)

This study suggests that targeting pathways such as YAP1 or GRB2 signaling and pathways regulating global histone acetylation could be beneficial in treating HCC with hyperactive mTOR signaling.

Keyphrases

dna methylation
cell proliferation
cancer therapy
emergency department
single cell
big data
gene expression
adverse drug
drug delivery
data analysis
drug induced