Differential Impact of Weight Loss and Glycemic Control on Inflammasome Signaling.

Luca AntonioliDiego MoriconiStefano MasiDario BottazzoCarolina PellegriniMatteo FornaiMarco AnselminoEle FerranniniCorrado BlandizziStefano TaddeiMonica Nannipieri

Published in: Obesity (Silver Spring, Md.) (2020)

Plasma IL-1β and caspase-1 levels were inversely correlated with IR. Caspase-1 levels normalized after weight loss, whereas IL-1β normalized only in people without T2D, suggesting the persistence of a systemic inflammatory condition in people with T2D.

Keyphrases

weight loss
glycemic control
bariatric surgery
roux en y gastric bypass
cell death
blood glucose
type diabetes
gastric bypass
induced apoptosis
oxidative stress
weight gain
obese patients
body mass index
physical activity