The double-edged sword of endoplasmic reticulum stress in uremic sarcopenia through myogenesis perturbation.

Jia-Rong JhengYuan-Siao ChenUn Iong AoDing-Cheng ChanJenq-Wen HuangKuang-Yu HungDer-Cheng TarngChih-Kang Chiang

Published in: Journal of cachexia, sarcopenia and muscle (2018)

Our studies indicated that the ER stress and UPR modulation are critical in the chronic kidney disease uremic toxin-accumulated sarcopenia model. We believe that UPR-related signals showed great potential in clinical application.

Keyphrases

endoplasmic reticulum stress
chronic kidney disease
induced apoptosis
skeletal muscle
end stage renal disease
escherichia coli
community dwelling
human health
peritoneal dialysis
oxidative stress
signaling pathway
climate change