Napabucasin overcomes cisplatin resistance in ovarian germ cell tumor-derived cell line by inhibiting cancer stemness.

Silvia SchmidtovaLambert C J DorssersKatarina KalavskaAd J M GillisJ Wolter OosterhuisHans StoopSvetlana MiklikovaZuzana KozovskaMonika BurikovaKatarina GercakovaErika DurinikovaMichal ChovanecMichal MegoLucia KucerovaLeendert H J Looijenga

Published in: Cancer cell international (2020)

The novel chemoresistant cells represent unique model of refractory oYST. CSC markers are associated with cisplatin resistance being possible targets in chemorefractory oYST.

Keyphrases

germ cell
induced apoptosis
papillary thyroid
stem cells
signaling pathway
cell cycle arrest
squamous cell
squamous cell carcinoma
endoplasmic reticulum stress
cell proliferation
childhood cancer
pi k akt
cancer stem cells