Bone Marrow-Derived Myofibroblasts Promote Gastric Cancer Metastasis by Activating TGF-β1 and IL-6/STAT3 Signalling Loop.

Jianzheng WangQingli LiXiaojiao ChengBaiwen ZhangJiacheng LinYao TangFuli LiChung S YangTimothy C WangShuiping Tu

Published in: OncoTargets and therapy (2020)

Our results demonstrated that BMFs promote gastric cancer metastasis through the activation of the TGF-β1 and IL-6/STAT3 signalling pathways. Targeting the inhibition of these interactions may be a potent therapeutic strategy for addressing gastric cancer metastasis.

Keyphrases

transforming growth factor
cell proliferation
signaling pathway
mesenchymal stem cells
bone marrow