Non-invasive fetal genotyping for maternal alleles with droplet digital PCR: A comparative study of analytical approaches.

Joe Shaw Elizabeth ScotchmanBen PaternosterMaureen RamosSarah NesbittSophie SheppardTristan SnowsillLyn S Chitty Natalie Jane Chandler

Published in: Prenatal diagnosis (2023)

ddPCR can be applied to RMD for diverse conditions and inheritance patterns, but all methods carry a small risk of erroneous results. Further evaluation is required both to reduce the rate of inconclusive results and explore discordant results in more detail.

Keyphrases

high throughput
mitochondrial dna
genome wide
single cell
birth weight
dna methylation
gene expression
pregnant women
weight gain