Metformin co-commencement at time of antipsychotic initiation for attenuation of weight gain: a systematic review and meta-analysis.
Ou YuMengyao LuTerence K Y LaiMargaret HahnSri Mahavir AgarwalBrian O'DonoghueBjørn H EbdrupDan J SiskindPublished in: Therapeutic advances in psychopharmacology (2024)
Metformin led to statistically significant and clinically meaningful attenuation of weight gain as well as attenuation of several other metabolic parameters when commenced concomitantly with antipsychotic medications. Co-commencement of metformin with antipsychotic medications, where tolerated, should be considered in the clinical setting with aim to improve long-term cardiometabolic outcomes for patients with long-term need of antipsychotic treatments.