The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex.

Lucas TophamStephanie GregoireHyungMo Kang Mali-Salmon Divon Elad Lax Magali MillecampsMoshe SzyfLaura Stone

Published in: Pain reports (2021)

These results suggest a role for the epigenome in the maintenance of chronic pain and advance epigenetic modulators such as SAM as a novel approach to treat chronic pain.

Keyphrases

chronic pain
dna methylation
neuropathic pain
spinal cord
spinal cord injury
genome wide
functional connectivity
gene expression
pain management
small molecule
copy number
working memory
amino acid
drug induced