Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome.
Anna K BonkhoffSungmin HongMartin BretznerMarkus D SchirmerRobert W RegenhardtE Murat ArsavaKathleen DonahueMarco NardinAdrian DalcaAnne-Katrin GieseMark R EthertonBrandon L HancockSteven J T MockingElissa McIntoshJohn Richard AttiaOscar BenaventeJohn W ColeAmanda DonattiChristoph GriessenauerLaura HeitschLukas HolmegaardKatarina JoodJordi Jiménez-CondeSteven KittnerRobin LemmensChristopher LeviCaitrin W McDonoughJames F MeschiaChia-Ling PhuahArndt RolfsStefan RopeleJonathan RosandJaume RoquerTatjana RundekRalph L SaccoReinhold SchmidtPankaj SharmaAgnieszka SlowikMartin SoederholmAlessandro SousaTara M StanneStrbian DanielTurgut TatlisumakVincent N ThijsAchala VagalJohan WasseliusDaniel WooRamin ZandPatrick McArdleBradford B WorrallChristina JernArne G LindgrenJane MaguirePolina GollandDanilo BzdokOna WuNatalia S RostPublished in: Neurology (2022)
Higher WMH burden may be associated with an increased stroke severity in case of stroke lesions involving left-hemispheric insular, opercular, and inferior frontal regions (potentially linked to language functions) and right-hemispheric temporoparietal regions (potentially linked to attention). Our findings suggest that patients with specific constellations of WMH burden and lesion locations may have greater benefits from acute recanalization treatments. Future clinical studies are warranted to systematically assess this assumption and guide more tailored treatment decisions.