RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer.
Satoshi NakamuraMasato KitazawaYusuke MiyagawaMakoto KoyamaSatoru MiyazakiNao HondoFutoshi MuranakaShigeo TokumaruYuta YamamotoTakehito EharaTomio MatsumuraMichiko TakeokaYuji SoejimaPublished in: Technology in cancer research & treatment (2023)
Overall, our findings indicate that RhoA G17E is associated with Vav1 and promoted cancer invasion via matrix metalloproteinase -9 in gastric cancer cells. Thus, RhoA G17E/Vav1 signaling in diffuse gastric cancer may be a useful therapeutic target.