Blackcurrant ( Ribes nigrum L.) improves cholinergic signaling and protects against chronic Scopolamine-induced memory impairment in mice.

Pauline da CostaMaria Rosa C SchetingerJucimara BaldissarelliNaiara StefanelloThauan F LopesKarine P ReichertCharles E AssmannNathieli B BottariVanessa V MironFermina Francesca A VargasJessié M GutierresIvana Beatrice Mânica da CruzVera Maria Morsch

Published in: Journal of psychopharmacology (Oxford, England) (2024)

Findings suggest that blackcurrant and Donepezil, either alone or in combination, have anti-amnesic effects by modulating cholinergic system enzymes and improving the redox profile. Therefore, blackcurrant could be used as a natural supplement for the prevention and treatment of memory impairment in neurodegenerative diseases.

Keyphrases

working memory
drug induced
signaling pathway
adipose tissue
combination therapy
oxidative stress
endothelial cells
skeletal muscle
insulin resistance
replacement therapy
stress induced