Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation.
Sakurako KobayashiNobuhiko OgasawaraSatoshi WatanabeYosuke YoneyamaSakura KirinoYui HiraguriMasami InoueSayaka NagataYoshimi Okamoto-UchidaSatoshi KofujiHiromichi ShimizuGo ItoTomohiro MizutaniShinichi YamauchiYusuke KinugasaYoshihito KanoYasuhiro NemotoMamoru WatanabeKiichiro TsuchiyaHiroshi NishinaRyuichi OkamotoShiro YuiPublished in: Inflammation and regeneration (2022)
Collagen type I showed a significant influence in the acquisition of the reprogrammed inflammatory signature in both mice and humans. Dissection of the cell fate conversion and its mechanisms shown in this study can enhance our understanding of how the epithelial signature of inflammation is influenced by the ECM niche.