CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice.
Jie LinYa XuPeiwen GuoYù-Jié ChenJiru ZhouMin XiaBinbin TanXin LiuHua FengYu-Jie ChenPublished in: Journal of translational medicine (2023)
CCR5 might be a potential target for the clinical treatment of infection-induced exacerbation of BBB disruption following ICH.
Keyphrases
- blood brain barrier
- cerebral ischemia
- dendritic cells
- regulatory t cells
- oxidative stress
- chronic obstructive pulmonary disease
- diabetic rats
- brain injury
- high glucose
- drug induced
- liver injury
- endothelial cells
- risk assessment
- replacement therapy
- combination therapy
- subarachnoid hemorrhage
- stress induced
- mechanical ventilation