The histone deacetylase inhibitor OBP-801 has in vitro/in vivo anti-neuroblastoma activity.

Daisuke KanedaTomoko IeharaKen KikuchiYohei SugimotoNorio NakagawaShigeki YagyuMitsuru MiyachiEiichi KonishiToshiyuki SakaiHajime Hosoi

Published in: Pediatrics international : official journal of the Japan Pediatric Society (2022)

Overall, OBP-801 induces M-phase arrest and apoptosis in neuroblastoma cells via mitotic catastrophe. Our results indicate that OBP-801 is a promising therapeutic agent with fewer adverse effects for patients with neuroblastoma.

Keyphrases

histone deacetylase
cell cycle arrest
induced apoptosis
cell cycle
endoplasmic reticulum stress
cell death
oxidative stress
pi k akt