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Neighbor cells restrain furrowing during epithelial cytokinesis.

Jennifer LandinoEileen MisterovichShahana A ChumkiAnn L Miller
Published in: bioRxiv : the preprint server for biology (2023)
Neighboring cells assemble actomyosin arrays adjacent to the cytokinetic furrowOverexpression of an F-actin cross-linker in neighbor cells slows furrowingOptogenetic activation of contractility in one neighbor pauses furrow ingressionHyper-contractility in both neighbors restrains furrowing & cells fail cytokinesis.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • signaling pathway
  • endoplasmic reticulum stress
  • oxidative stress
  • smooth muscle