Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production.
Sangshan TianDevendra PaudelFuhua HaoRabin NeupaneRita CastroAndrew D PattersonAmit K TiwariK Sandeep PrabhuVishal SinghPublished in: Cancer reports (Hoboken, N.J.) (2023)
Our study uncovers that supplementation of diet with refined inulin induces abnormal succinate accumulation in the intestinal lumen, which in part contributes to promoting colon inflammation and tumorigenesis.