A new Zn(II) coordination polymer based on o -phthalato (Phth) and 2-aminopyridine (2-Ampy) viz. {[Zn(2 - Ampy) 2 (Phth)]∙(H 2 O)]} n ( 1 ) has been synthesized at room temperature and characterized by elemental analyses, electronic spectroscopy, FT - IR spectroscopy, thermal analysis (TGA/DSC), powder X - ray diffraction (PXRD) and single crystal X - ray diffraction. The basic trimeric units of 1 form a polymeric chain by N-H∙∙∙O and π∙∙∙ π interactions. These polymeric chains interconnect through various non-covalent interactions in two perpendicular directions to ultimately give rise to a 3D architecture of 1 . The interesting non-covalent interactions in 1 , contributing to its stability in the solid state are studied by Hirshfeld surface analysis and other different theoretical tools. Molecular docking study of 1 is performed against six different proteins of SARS-CoV-2. The drug potential of the synthesized compound is evaluated by ADMET calculations.